IL12RB1 and Salmonella Infections: Autosomal recessive IL-12B or IL-12Rβ1 gene mutations, causing IL-12Rβ1 or IL-12p40 deficiency, affecting both IL-12 and IL-23 signaling pathways, leads to mycobacterial infections in 83% of patients, to Salmonella infections in 43% and CMC in 23% of patients [74].