Furthermore, it has been reported that 27HC promotes proliferation of ERα-positive LNCaP prostate cancer cells via ERβ (Lau et al. 2000, Raza et al. 2017) which may account for the apparent discrepancy between ERE reporter assay and cell proliferation responses in RL95 cells observed in the current study. Here, ESR2 is linked to Familial prostate cancer.