Finally, CSF NfL discriminated PD from OND patients (age-adjusted AUC = 0.69, 95% CI 0.56–0.81) with a sensitivity of 0.97 (95% CI 0.90–1.00) and a specificity of 0.42 (95% CI 0.25–0.58) (Fig. 2). This evidence concerns the gene NEFL and Parkinson disease.