NFKB1 and neoplasm: Upon activation by certain inflammatory stimuli, cytokines, carcinogens, free radicals, tumor promoters, UV-light, γ-rays, and x-rays, the subunits p50 and p65 translocate into the nucleus, bind to the promoters region of various genes, and activate more than 400 genes that are involved in inflammation and other chronic diseases [12] (Fig. 1).