STAT3 and arthritic joint disease: However, if the inflammation continues, the second stage of inflammation called chronic inflammation commences which instigates various kinds of chronic diseases, including arthritis, cancer, cardiovascular diseases, diabetes, and neurological diseases via dysregulation of various signaling pathways such as nuclear factor kappa-B (NF-κB), signal transducer and activator of transcription 3 (STAT3) etc. [5].