Moreover, Cin also attenuated the colonic damage in trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats; decreased acute pulmonary inflammation in vivo; ameliorated acute pancreatitis in vivo via downregulation of cytokines, oxidative stress and NF-κB [38, 65, 66]. This evidence concerns the gene NFKB1 and acute pancreatitis.