TLR5 and systemic lupus erythematosus: Other investigators have previously reported the use of various BTK inhibitors in lupus models, including NZB/W, MRL/lpr, SLE1,3, and BXSB-Yaa strains and nephrotoxic serum nephritis (the latter a nephritis-limited model inducible in non-autoimmune mice following passive transfer of nephritogenic antibodies).