CCN5 is a 29–35 kDa secreted protein with long half-life (~ 53 h), and is overexpressed in preneoplastic disorders in the human breast, including atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS) compared with adjacent invasive cancer cells where expression levels were undetected, minimally detected, or only sporadically detected [38]. This evidence concerns the gene CCN5 and ductal breast carcinoma in situ.