LEP and obesity disorder: The mechanisms through which obesity may influence the disease process include an excess production of estrogen by adipose tissue aromatase (peripheral aromatization), reduced levels of sex hormone-binding globulin with consequent rise of the bioactive/free estradiol, increased biosynthesis of insulin-like growth factors (IGFs) and adipose tissue secreted factors like leptin, which is involved in various physiological functions such as sense of satiety, energy metabolism, fertility, immune response and hematopoiesis [15, 16].