To date, several factors were identified as the risk factors of cardiovascular calcification, including metabolic disorder of calcium, phosphorus, parathyroid hormone, and fibroblast growth factor 23, inflammation, oxidative stress, declining of calcification inhibitor such as fetuin-A and matrix Gla protein, as well as pharmacological interventions such as active vitamin D and calcium-based phosphate binders. Here, FGF23 is linked to metabolic disease.