In addition, they had increased CRP and transaminases, suggesting some degree of underlying inflammation and non-alcoholic steatohepatitis, which have been previously associated with oxidative stress in obese children [2,26,27], and with an accelerated free fatty acid flux to portal circulation and serum AGEs accumulation in adults with metabolic syndrome [28,29]. This evidence concerns the gene CRP and metabolic dysfunction-associated steatohepatitis.