GPT and Skin rash: Besides, side effects like abnormal liver function (i.e., serum Alanine transaminase [ALT] and/or Aspartate transaminase [AST] activity increased [43]) (7% vs. 6%), skin rash (3% vs. 1%), golssitis (1% vs. 0%) and constipation (0% vs. 2%) were rarely observed in patients receiving either high-dose or low-dose therapies.