On the other hand, mice immunized with HAv-SF-10 and then depleted of CD8+ T cells in the severe pneumonia model showed a mild decrease in the survival rate from 80 to 60% (P = 0.364, vs without depletion) (Fig 5C), and also showed mild delay in recovery of body weight loss (Fig 5D). The gene discussed is CD8A; the disease is pneumonia.