Similar data have been obtained in different animal models: Hematopoietic stem cells (HSCs) and expanded CD8+ CIK cells from C57BL/6, as well as control splenocyte mice, were introduced into lethally irradiated MHC-mismatched Balb/c recipients together with Balb/c BCL-1 lymphoma. This evidence concerns the gene CD8A and lymphoma.