The role of serotonin in the pathophysiology of asthma is well established, as 5-HT2A stimulates different signaling pathways and regulates cytokine release in airway epithelial cells.[17] 5-HT2A has also been reported to play a role as a mediator of inflammation in the immune response outside the central nervous system.[18] Both serotonin and eotaxin have been recently described as having an eosinophil chemoattractant profile, which may explain the connection between the pathogenesis of AEP and CEP and antipsychotic and antiepileptic drugs.[12]. The gene discussed is HTR2A; the disease is asthma.