In the BC sample comprising 4641 familial BC index patients without a personal or familial OC history, nine patients carried heterozygous BRIP1 LoF mutations, resulting in a cumulative carrier frequency of 0.19% (OR = 1.42, 95% CI = 0.70–2.90, P = 0.3030; Table 1). The gene discussed is BRIP1; the disease is breast cancer.