Buys et al. identified truncating BRIP1 mutations in 110 of 33,767 mainly familial BRCA1/2-negative BC index patients, resulting in a cumulative carrier frequency of 0.33% [11], which is approximately two-fold higher than that described in the Exome Aggregation Consortium (ExAC) database (Table 1). This evidence concerns the gene BRCA1 and breast cancer.