In the differential diagnosis between AD and other NDs (FTLD and DLB), NfL accuracy (AUC 0.623 ± 0.046) was quite lower than that of Aβ42, t-tau, and p-tau alone (AUC from 0.775 to 0.919) (Additional file 1: Table S2). This evidence concerns the gene MAPT and Alzheimer disease.