Otherwise, in the specific comparisons between prion disease and DLB and between prion disease and FTLD, the diagnostic accuracy of t-tau (AUC 0.963 ± 0.015; 0.982 ± 0.009) was superior to that of NfL (AUC 0.880 ± 0.047; 0.870 ± 0.032), and the t-tau/p-tau ratio (AUC 0.970 ± 0.019; 0.983 ± 0.010) was the best biomarker (see Additional file 1: Table S2). This evidence concerns the gene NEFL and Lewy body dementia.