EGF and neoplasm: Compared to the macrophages in WT group samples, the macrophages isolated from PKN2-WT tumor showed significantly higher expression of Il1b, Tnf, Cxcl9, Il23, Ros1 and Il12b and significantly lower expression of Tgfb1, Vegfa, Egf, Retnla and Il10, illustrating predominant M1 phenotype.