Compared to the macrophages in WT group samples, the macrophages isolated from PKN2-WT tumor showed significantly higher expression of Il1b, Tnf, Cxcl9, Il23, Ros1 and Il12b and significantly lower expression of Tgfb1, Vegfa, Egf, Retnla and Il10, illustrating predominant M1 phenotype. The gene discussed is VEGFA; the disease is neoplasm.