MALAT1 and colorectal carcinoma: For instance, lncRNA colon cancer-associated transcript-2 (CCAT2), elevated in CRC, might repress the processing and maturation process of miR-145 in the nucleus, thereby restraining the proliferation and differentiation of CRC stem cells [25]; Additionally, as another lncRNA implied to interact directly with the serine/arginine splicing factor 1 in HeLa cells and influence the distribution and phosphorylation of the splicing factor, MALAT1 could potentially modulate the alternative splicing of pre-mRNAs, thus being involved in mRNA processing [26].