As another representative of functional protein, TP53 could directly upregulate lncRNA LOC401317 in NPC cells, thereby suppressing tumor growth [123].Third, genetic changes such as single-nucleotide polymorphisms (SNPs) or epigenetic alterations within the non-coding genome could markedly affect the transcription of lncRNA; for instance, in PTC, the polymorphism of rs944289 in 14q13.3 could reduce the level of lncRNA PTCSC3 by abolishing the binding domain of CCAAT/enhancer binding proteins α and β and subsequently inhibiting the activation of the PTCSC3 promoter [124]. This evidence concerns the gene PTCSC3 and nasopharyngeal carcinoma.