AKT1 and metastatic malignant neoplasm in the lymph nodes: Specifically, MALAT1 was indicated to be associated with the lymph node metastasis (LNM) of ESCC, contributing to its migratory and invasive abilities [30]; likewise, it promotes the metastasis of osteosarcoma in vitro and vivo through the phosphatidylinositol 3-kinase-protein kinase B (PI3K-AKT) pathway [31].