HOTAIR and nasopharyngeal carcinoma: HuR, as an RBP, could form a regulatory circuit with HOTAIR and contribute actively to the stability and expression of HOTAIR in HNC [47]; similarly, HuR could regulate the stability of lnc-Sox5 and lead to TSCC progression [120]; in addition, another RBP, RNA-binding protein 24 could degrade MALAT1 by directly upregulating miR-25 expression, revealing the synergistic effect of RBP and miRNA on regulating lncRNA in NPC [121].