HSPA9 and cancer: By establishing local contact points between ER and mitochondria, GRP75 has a major role in maintaining crosstalk between these organelles through coordinating the exchange and transfer of Ca2+, and to drive subsequent signaling cascades.11,20–23 GRP75 has been extensively studied in various cancer cells where its expression increased susceptibility to cell death.24,25 However, the consequences of an alteration in GRP75 expression to neuronal cell survival are not entirely clear.