Similarly, GRP75 downregulation by small hairpin RNAs or anti-peptides induced apoptosis in HepG2 liver cancer cells, and this effect was attributed to reduced GRP75–p53 interaction and concomitant nuclear p53 translocation in these cells.52 In contrast, in our study, MKT-077 reduced ER–mitochondrial contact points and conferred protection against oxidative glutamate toxicity suggesting the disconnection of ER and mitochondria as an underlying mechanism for the observed protection after GRP75 inhibition in HT22 cells. This evidence concerns the gene TP53 and liver cancer.