Remarkably, the development of the EM phenotype of CD8+ T cells against HCMV pp65 follows analogous kinetics upon primary infection of HCMV-seronegative patients receiving a HCMV-positive kidney transplant as compared to the EM phenotype of the inflationary MCMV epitopes (Figures 2B and 3E). The gene discussed is CD8A; the disease is infection.