That antibodies elicited by mE1E2bv and pmE1+E2 VLPs did not result in ADE (Figure 6A) was corroborated by the finding of lowered levels of small intestinal TNF-α (Figure 7A) and IL-6 (Figure 7B) in the mice which received ICs generated with anti-mE1E2bv VLP and anti-pmE1+E2 VLP antisera. This evidence concerns the gene PPME1 and acute disseminated encephalomyelitis.