PPME1 and acute disseminated encephalomyelitis: Reduction in TNF-α levels (Figure 7A) in AG129 mice in the ‘V+αE1E2bv VLP ICs’ (p = 0.0139) and the ‘V+pmE1+E2 VLP ICs’ (p = 0.0453) groups was statistically significant compared to TNF-α levels in the ‘V+4G2 ICs’ group which manifested high mortality due to ADE.