DNAJC5 and Parkinson disease: Intriguingly, C. elegans DJ-27, an ortholog of mammalian ERdj5, showed a protective effect against aggregate formation, behavior abnormalities, and mitochondrial fragmentation in worm models of human Alzheimer, Parkinson, and Huntington diseases (Munoz-Lobato et al., 2014); these findings suggest that DNAJC5 may counteract protein misfolding/aggregation toxicity in neuronal cells.