To determine whether IGF signaling affects breast cancer progression, metastasis and response to paclitaxel, a standard chemotherapeutic agent used to treat breast cancer, we treated mice orthotopically implanted with Py230 TNBC cells, with control IgG antibody, IGF-1/2 blocking antibody xentuzumab, paclitaxel, or xentuzumab with paclitaxel (Fig. 5a). Here, IGF1 is linked to breast carcinoma.