INS and breast carcinoma: Immunohistochemical staining of serial sections of non-malignant breast tissue (Fig. 1a) and breast cancer patients’ tissues (Fig. 1b, c) revealed an increase in phospho-insulin/IGF-1 receptor levels in the breast cancer tissues along with increased infiltration of CD68+ (pan-myeloid/macrophage marker) and CD163+ (marker commonly used to identify pro-tumorigenic M2-like macrophages) macrophages (Fig. 1a–d).