In agreement with the present experimental work, C57BL/6 J × 129/Ola mice infected with 106 PbA iRBCs presented significantly elevated levels of IL-10 under infection, mainly in those not suffering CM12; and 129 Sv/Ev mice infected with 106 or 5 × 105 PbA iRBCs showed IL-10 mRNA expression in the brain; however, they developed ECM at 6–9 d.p.i.9. The gene discussed is IL10; the disease is infection.