The expression of intercellular adhesion molecule-1 (ICAM-1) is upregulated on the cerebral vasculature endothelium of humans during malaria infection, and it is one of the major receptors involved in the sequestration of infected P. falciparum red blood cells within the brain, which is described in cerebral malaria (CM)6. The gene discussed is ICAM1; the disease is cutaneous mastocytosis.