Our data showed that 18 viral genes (UL29, UL32, UL34, UL36, UL37, UL44, UL50, UL56, UL82, UL84, UL95, UL105, UL112, UL117, UL123, US3, US31, and TRS1) were detected in the PBMCs of at least one of the three SLE patients. The gene discussed is RPS3; the disease is systemic lupus erythematosus.