Ephrin-A1, the first identified ligand for an Eph receptor, is overexpressed in BCa5 and induces endothelial cell migration and capillary assembly in vitro6, suggesting a critical role in inducing tumor angiogenesis through its EphA2 receptor localized primarily on tumor-associated vascular endothelial cells7,8. This evidence concerns the gene EFNA1 and neoplasm.