Compared to the BBN control group, MVD significantly decreased upon LEF treatment at doses of 10.0 and 20.0 mg/kg/day in a dose-dependent manner (p < 0.05, Fig. 6B,D), indicating that LEF may have protective effects through the suppression of ephrin-A1, with a subsequent anti-angiogenic effect in tumor tissues. The gene discussed is EFNA1; the disease is neoplasm.