Although we did not observe that HOXC8 affected the expression of N-cadherin or cadherin-11, we demonstrated that HOXC8 expression markedly decreased E-cadherin expression and increased vimentin and TGFβ1 expression in lung cancer cells, indicating that HOXC8 plays an important role in the EMT process of lung cancer cells. The gene discussed is CDH11; the disease is lung carcinoma.