In a model (Fig. 6c) we illustrate that the exposure to paclitaxel induces UBC13 down-regulation, a decline in UBC13 increases DNMT1 expression via ubiquitination inhibition, elevated DNMT1 reduces the CHFR level through promoter hypermethylation, and subsequently up-regulates the amount of Aurora A in ovarian cancer cells. Here, UBE2N is linked to ovarian carcinoma.