DNMT1 and ovarian carcinoma: Furthermore, we found a reverse regulation of DNMT1 by siRNA in the resistance to paclitaxel induced by UBC13 down-regulation in ovarian cancer cells and a prolonged DNMT1 protein half-life in the paclitaxel resistant ovarian cancer cells, suggesting that DNMT1 participates in the process of UBC13 regulation of the sensitivity to paclitaxel in ovarian cancer cells.