We cultured A2780 and SKOV3 cells with paclitaxel at different times (3, 6, 12, 24 h) and concentrations (2, 5, 10 nM), to observe the expression of the UBC13 protein, and the coinstantaneous response of the above four molecules in ovarian cancer cells to drug exposure. This evidence concerns the gene UBE2N and ovarian cancer.