ACE and stroke disorder: Renin-Angiotensin System (RAS) blockades—angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blockers (ARBs) were frequently prescribed antihypertensive agents for stroke patients in anticipation of “beyond blood pressure (BP) lowering” effect that attenuate the vicious cascade such as vascular remodeling, endothelial dysfunction, oxidative stress and inflammation2,3.