ERBB2 and familial pancreatic carcinoma: In regard to the effect of CHIP on cancer cell growth, CHIP primarily impedes tumor progression through degradation of several cell-proliferation-, cell-survival-, and angiogenesis-related proteins, such as ErBb2, c-Myc, EGFR, and HIF-1α, in diverse cancer types (i.e., breast, gastric, and pancreatic cancer).