STUB1 and neoplasm: As shown in Fig. 7a, A549 tumors expressing mock, CHIP-WT, or CHIP-KR grew rapidly in the absence of IFN-α treatment with average tumor size reaching 364.9 ± 104.5, 200.4 ± 60.3, or 264.8 ± 25.4 mm3 by day 21 following cell implantation, respectively.