GPAM and breast cancer: We performed bioinformatics analysis of the data from the miRDB, Targetscan, Pictar, and miRanda websets to explore the molecular mechanism of miR-27a as an oncogenic molecule in breast cancer, and found that six genes are overlapped, namely TMEM170B, GPAM, PPAP2B, ST6GALNAC3, EYA1, and PPARG (Supplementary Fig. 1f).