We performed bioinformatics analysis of the data from the miRDB, Targetscan, Pictar, and miRanda websets to explore the molecular mechanism of miR-27a as an oncogenic molecule in breast cancer, and found that six genes are overlapped, namely TMEM170B, GPAM, PPAP2B, ST6GALNAC3, EYA1, and PPARG (Supplementary Fig. 1f). This evidence concerns the gene PLPP3 and breast cancer.