HOTTIP and small cell lung carcinoma: miR-216a were screened out from 28 miRNAs after miRNA microarray for being related closely to SCLC chemoresistance (Supplementary Figures 2D-2E, Supplementary Table 3), and it was predicted by the bioinformatics website RNA22-seq (https://cm.jefferson.edu/) that it has targeted binding relationship with HOTTIP (Fig. 6a).