To investigate the role of HOTTIP in SCLC chemoresistance, PCR-based gene expression profiling array was performed in paired human SCLC cell line H69 and its drug resistance cell line H69AR, the results showed a differential expression of 16 HOX family members, among which HOXA13 gene and lncRNA HOTTIP that is on the physical proximity of HOXA gene were upregulated most remarkably in H69AR cell. Here, HOTTIP is linked to small cell lung carcinoma.