According to the targeting regulation relationship between miR-216a and BCL-2, we further investigated whether BCL-2 was involved in SCLC chemoresistance and cell apoptosis, and the results showed that BCL-2 knockdown exactly enhance sensitivity to chemotherapy drugs (Fig. 7e) and H69AR cell apoptosis (Fig. 7f). Here, BCL2 is linked to small cell lung carcinoma.