ADRB2 and heart failure: Moreover, an elegantly-designed study by Perera et al. [158] proved experimentally for the first time that, in early compensated cardiac hypertrophy preceding heart failure, cGMP-sensitive PDE2 and PDE3 were already physically and functionally rearranged between β1- and β2-AR-associated cAMP microdomains despite unchanged whole cell expression levels and activities.