Mutations in several transcription factors such as HAND1, HAND2, TBX5, GATA4, NKX2.5 and TBX20 have been identified in patients affected with distinct congenital heart diseases, such as atrial septal defects (TBX5, GATA4, NKX2.5, TBX20), Tetralogy of Fallot (TBX5, TBX20), ventricular septal defects (HAND2), double outlet right ventricle (HAND1), either syndromic (Holt-Oram; TBX5) or isolated (see for recent reviews [110,111]). Here, GATA4 is linked to congenital heart disease.