NPPB and mitral valve insufficiency: As shown in Table 2 NT-proBNP was significantly and negatively correlated with the left ventricular ejection fraction (LVEF), TAPSE, hemoglobin, and GFR-EPI; it was positively and significantly correlated with age, NYHA class, left ventricular end-systolic volume (LVESV), E/e’ ratio, mitral regurgitation (MR) severity, tricuspid regurgitation (TR) severity, Pulmonary artery systolic pressure (PAPS), and central venous pressure (CVP).