Interestingly, only for active Lyme neuroborreliosis patients was an association found between the number of Osp mix-specific IFN-γ-secreting T cells/2.5 × 105 PBMCs and the number of B. burgdorferi B31-specific IFN-γ-secreting T cells/2.5 × 105 PBMCs (rs, 0.723; P < 0.001; n = 21) (data not shown). The gene discussed is IFNG; the disease is Lyme disease.