To determine if stabilization of A3A protein also occurs in HPV-positive cancer cells, we evaluated the turnover of A3A protein in HPV-positive CxCa (CaSki) and HNC (SCC-90 and SCC-152) cell lines and compared it to that in HPV-negative CxCa (C33A) and HNC (SCC-25) cell lines. This evidence concerns the gene APOBEC3A and cancer.