The interaction between temperamental features and neurobiological markers appears a key concept for identifying the “more affected” group of mothers’ perceptions, “for better and for worse”; the same neurobiological marker, i.e., the dopamine 7r allele of DRD4, appears to play a role in decreasing their children’s behavioral problems report if in interaction with the temperamental feature of mother’s EC and, conversely, in increasing the same perception if in interaction with mother’s NA [15]. This evidence concerns the gene DRD4 and Atypical behavior.