Notably, CYR61 was highly expressed in a more advanced gastric adenocarcinoma specimen, and the human gastric cancer cell line overexpressing CYR61 significantly increased tumor cell motility and invasion through activation of the integrin/nuclear factor-kappa B (NF-κB) p65/cyclooxygenase-2 signaling pathway. Here, CCN1 is linked to gastric adenocarcinoma.