Recently, van Kampen with co‐authors showed the ability of the bone marrow‐derived HSPCs from the normal recipient mice to which hypercholesterolaemia‐primed HSPCs were engrafted to induce hypomethylation of CpG regions in the PU.1 and interferon regulatory factor 8 (IRF‐8) genes 80. This evidence concerns the gene IRF8 and Hypercholesterolemia.