To investigate whether RECK overexpression can counteract the tumour growth caused by miR‐15b, we cotransfected RECK and miR‐15b overexpression vectors into 22RV1 and PC3 cells and found that RECK overexpression attenuated cell proliferation (Fig. 5A) and invasion promoted by miR‐15b (Fig. 5B). This evidence concerns the gene RECK and neoplasm.