PIAS3 and neoplasm: ZFHX3 is a transcription factor of zinc ring structure, can be combined with AT-rich enhancer motif, also is called ATBF1 (AT-motif binding factor 1), involved in embryonic development, neuronal differentiation, response to DNA damage and thermal stress, and tumor inhibitory [41–44], and interacts with PIAS3 to regulate STAT3-mediated signaling transduction pathways [45].