EGFL7 activates EGFR-related pathways by two EGF-like domains (22,23); this is consistent with the results of certain clinical studies that demonstrated that EGFR has been clinically detected to have high levels of expression in human osteosarcoma cells (7) and can be verified as a therapeutic target in osteosarcoma (24). This evidence concerns the gene EGFL7 and osteosarcoma.