We found that the majority of the TFs in the extracted rule have reported cell-type or tissue-specific expression specificities, such as IRF in lymphoblastoid cell-line [46, 47], AP-1 in cervical cancer [48, 49], HNF4 in liver and colon cells [50], LMO2 [51] and GATA in leukaemia cells [52, 53]. The gene discussed is HNF4A; the disease is leukemia.