It has been reported that ethanol can increase the invasion of breast cancer cells by modulating matrix metalloproteinase-2 (MMP-2) (Aye et al. 2004), while PhIP also increased the invasiveness of breast cancer cells (Lauber and Gooderham 2011), therefore, together these two compounds can potentially support and promote the progression of mammary cancer. This evidence concerns the gene PHIP and breast cancer.