Alongside comparable plasma levels of bone disorder biomarkers—including serum calcium and phosphate, 25-OH vitamin D, 1,25-OH vitamin D, PTH, and FGF23—the average values of S100A12/ENRAGE, pentosidine, RAGE, and myeloperoxidase at baseline were very similar in the two study arms (Table 1). This evidence concerns the gene S100A12 and bone disorder.