Pernicious anemia has an association with HLA-DR5 for a relative risk of 5, Hashimoto's thyroiditis partnering with the HLA-DR3 for a relative risk of 3.2 and HLA-DR5 for a relative risk of 5.8 [17], the autoimmune diabetic subjects, 90% of the Caucasian population associated with HLA-DR3 and/or DR4. This evidence concerns the gene TNFRSF10A and Hashimoto thyroiditis.