In line with these notions, we observed that an icv injection of visfatin enhanced the activities of POMC neurons and determined that anorexia and body weight loss induced by visfatin injection were effectively reversed by treatment of a synthetic antibiotics, which inhibit the microglia activation, suggesting that visfatin contributes to the brain control of energy balance, at least in part, via the inflammatory process in the hypothalamic microglia, affecting the activity of POMC neurons. Here, POMC is linked to Anorexia.