Although no statistically significant association (P > 0.05) was observed with regard to dyslipidemia and increased risk to CHD in this study, the 1.88-fold increase of hypercholesterolemia and the higher statistically significant association of the DD genotype at the APOB signal peptide locus may implicate the role of this polymorphism in increasing the risk to CHD independently. The gene discussed is APOB; the disease is familial hypercholesterolemia.