The statistically significant association of ethnicity (P < 0.001) and the known risk factors (P < 0.005), such as smoking (32.3%; OR of 6.69), hypertension (55.1% of CHD patients), medical history of T2DM (53.1%; OR of 5.73), hypercholesterolemia (OR of 1.85), and family history of CHD (OR of 1.69) in addition to the newly identified APOB rs11279109 DD genotype (OR of 2.43), all contribute to the increased risk of CHD possibly through the development of different mechanisms leading to arthrosclerosis as a result of LDL oxidation. The gene discussed is APOB; the disease is Hypercholesterolemia.