Diabetes increased cell senescence, as reflected by increased expression of senescence markers (p16INK4A and p21WAF1/CIP) (Fig. 4f) and senescence-associated β-galactosidase (SA-β-gal) activity (Fig. 4g) at the 3 and 6 months DM time points, and these cell senescence indices were significantly attenuated by PFT-α. The gene discussed is CDKN2A; the disease is diabetes mellitus.