Inversely, the negatively regulated genes by mTOR signaling (gene set: MTOR_UP.N4.V1_DN, Fig. 5, right) were enriched in the PGAM1-low expression groups, in both lung adenocarcinoma (ADC) (Fig. 5a) and lung squamous cell carcinoma (SCC) (Fig. 5b) subtypes of NSCLC. This evidence concerns the gene PGAM1 and AIDS dementia complex.