Inversely, the negatively regulated genes by mTOR signaling (gene set: MTOR_UP.N4.V1_DN, Fig. 5, right) were enriched in the PGAM1-low expression groups, in both lung adenocarcinoma (ADC) (Fig. 5a) and lung squamous cell carcinoma (SCC) (Fig. 5b) subtypes of NSCLC. The gene discussed is PGAM1; the disease is squamous cell lung carcinoma.