To assess the physiological function of EBAG9 in host defense against prostate cancer development, we used a model of Ebag9 knockout (Ebag9KO) mice13 crossed with TRAMP mice (C57BL/6-Tg(TRAMP)8247Ng/J obtained from Jackson Lab), which are characterized to develop spontaneously transgenic adenocarcinoma of the mouse prostate22. The gene discussed is EBAG9; the disease is Familial prostate cancer.